Sample genealogies and genetic variation in populations of variable size

We consider neutral evolution of a large population subject to changes in its population size. For a population with a time-variable carrying capacity we have computed the distributions of the total branch lengths of its sample genealogies. Within the coalescent approximation we have obtained a general expression – Eq. (27) – for the moments of these distributions for an arbitrary smooth dependence of the population size on time. We investigate how the frequency of population-size variations alters the distributions. This allows us to discuss their influence on the distribution of the number of mutations, and on the population homozygosity in populations with variable size.